The recommended dosage of zerbaxa for injection is 1. Avycaz is a combination of ceftazidime, a cephalosporin, and avibactam, a betalactamase inhibitor, indicated for the treatment of the following infections caused by designated susceptible gramnegative microorganisms. Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4 may 2020. Selected safety information patients with renal impairment. Dosage of avycaz in adult patients with creatinine clearance crcl greater than 50 mlmin 2. Before infusion, dilute the withdrawn volume of the constituted avycaz solution further with the same diluent used for constitution of the powder except sterile water for injection, to achieve a total volume between 50 ml ceftazidime 0. Highlights of prescribing information zerbaxa 750 mg 250. Ceftazidime is a semisynthetic, betalactam antibacterial drug. Avycaz reference guide for safe and effective use from the american society of. Avycaz ceftazidimeavibactam for injection package insert. Indications avycaz ceftazidime and avibactam hcp site. Escherichia coli, klebsiella pneumoniae, proteus mirabilis. Avycaz ceftazidimeavibactam for injection, for intravenous use.
The approved package insert reflects an updated dosing regimen and recommends crcl be monitored at least daily with doses adjusted accordingly, especially in patients with changing renal function. Ceftazidimeavibactam avycaz, actavis september 2015. Find information on ceftazidimeavibactam avycaz in daviss drug guide including dosage, side effects, interactions, nursing. Adult patients with severe renal impairment creatinine clearance 30 mlmin1. To prevent such errors, vial labels and carton packaging were revised to. Invanz may be used for the treatment of infections in adult patients with renal impairment.
Indicated in combination with metronidazole for complicated intraabdominal infections ciais in adult and pediatric patients. Highlights of prescribing information these highlights do not include all the information needed to use zerbaxasafely and effectively. The diluted solution must have a final dalbavancin concentration of 1 mgml to 5 mgml. Aseptically transfer the required dose of reconstituted dalbavancin solution. Avycaz ceftazidime and avibactam, in combination with metronidazole, is indicated for the treatment of complicated intraabdominal infections ciai, in adult and pediatric patients 3 months or older caused by the following susceptible gramnegative microorganisms. The ceftazidime component of avycaz is a thirdgeneration cephalosporin with in vitro activity against certain gramnegative and grampositive bacteria. The reconstituted vial contains 20 mgml dalbavancin as a clear, colorless to yellow solution. Ceftazidimeavibactam is used to treat certain multidrugresistant gramnegative infections. Dailymed avycaz ceftazidime, avibactam powder, for solution. Zerbaxa ceftolozane and tazobactam for injection, for intravenous use initial u.
Yearly, nearly 9300 healthcareassociated enterobacteriaceae. Aseptically transfer the required dose of reconstituted dalbavancin solution from the vials to an intravenous bag or bottle containing 5% dextrose injection, usp. The search was limited to studies performed in human and published in. In a clinical trial, patients with ciais with crcl 50 mlmin had a clinical cure rate of 85. Antimicrobial activity ambisome has shown in vitro activity comparable to amphotericin b against the following organisms. Decreased efficacy of zerbaxa has been observed in patients with baseline crcl of 30 to. See full prescribing information for dosage for ciai or cuti in pediatric patients 2 years and. Avycaz ceftazidime and avibactam for injection, for intravenous use initial u. Healthcare professionals, find information about avycaz ceftazidime and avibactam. Highlights of prescribing information these highlights do not include all the information needed to use eylea safely and effectively. Escherichia coli, klebsiella pneumoniae, proteus mirabilis, enterobacter cloacae, klebsiella oxytoca, citrobacter freundii complex, and pseudomonas aeruginosa. Extracted from avycaz package insert, section 6, table 4 were there any differences in side effects among sex, race and age. Avycaz ceftazidime and avibactam is indicated for the treatment of complicated urinary tract infections cuti including pyelonephritis in adult and pediatric patients 3 months or older caused by the following.
In these cases it is often used in combination with metronidazole, which provides coverage for anaerobic pathogens. Ceftazidimeavibactam is available as an intravenous iv formulation. Avycaz is contraindicated in patients with known serious hypersensitivity to the components of avycaz ceftazidime and avibactam, avibactamcontaining products, or other members of the cephalosporin class. Adverse effects adverseeffects adverseevent avycaz merrem vomiting 5% 2% nausea 3% 2% pruritus 2% 1%. Bumetanide is a loop diuretic, available in 4 ml and 10 ml vials for intravenous or intramuscular injection as a sterile solution. Insert an airway needle to relieve pressure and avoid product loss. The bactericidal action of ceftazidime is mediated through binding to essential penicillinbinding proteins. Among antibioticresistant bacteria, carbapenemresistant enterobacteriaceae cre have been described as an urgent threat by the cdc. Ceftazidimeavibactam was approved by the food and drug administration fda on.
For treatment of ciai, metronidazole should be given concurrently. The crisis of bad bugs, no drugs has led to the infectious diseases society of america 10 x 20 initiative, the national action plan for combating antibioticresistant bacteria, carbx, and other efforts to combat or call attention to drugresistant bacteria. Indicated for treatment of hospitalacquired bacterial pneumonia and ventilatorassociated bacterial pneumonia habp. Easytoread drug name and dosage strength to aid in identifying the right product. Discard any unused portion of the reconstituted solution. Following iv administration of fixed combination of ceftazidime and avibactam, pharmacokinetic parameters for ceftazidime and avibactam are similar to those reported when each drug is administered alone. Ceftazidimeavibactam avycaz for the treatment of complicated intraabdominal and urinary tract infections. Learn about the avycaz indications for habpvabp, cuti, and ciai. There are limited treatment options for infections due to multidrugresistant gramnegative pathogens such as esblproducing enterobacteriaceae and p. Bar codes included on the vial and carton for ease of scanning. Ceftazidime for injection, usp sagent pharmaceuticals. The components of ceftazidimeavibactam are formulated in a 4. According to the prescribing information, ceftazidimeavibactam should be reserved for use in patients who have limited or no alternative treatment options. Prescribing information home indications clinical data.
The package insert states decreased efficacy seen in patients with a baseline creatinine clearance provides accurate and independent information on more than 24,000 prescription drugs, overthecounter medicines and natural products. T o the e ditor the centers for disease control and prevention cdc has estimated that 2 million people in the united states are infected each year with antibioticresistant bacteria. Avycaz ceftazidimeavibactam is an antibacterial combination drug used to treat complicated intraabdominal infections ciai, used in combination with metronidazole. Avycaz ceftazdime and avibactam for injection for healthcare. Aspergillus fumigatus, aspergillus flavus, candida albicans, candida krusei, candida lusitaniae. Welcome to the information on this site is intended for health care professionals in the united states, its territories, and puerto rico and is not intended for the general public. Recommended dosage the recommended dosage of avycaz is 2. Indicated for complicated urinary tract infections cuti, including pyelonephritis, caused by escherichia coli, klebsiella pneumoniae, proteus mirabilis, and pseudomonas aeruginosa.